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Proteins perform a vast array of functions within living organisms. This unit will covering a range of high profile, contemporary topics in Protein Science, from folding and assembly through to dynamics and membrane transport. You will also study how structural studies of macromolecular assemblies are leading to the development of nanodevices.

• BIOL21111 Proteins (Compulsory)

The unit aims to provide students with an introduction to modern Protein Science, covering a representative range of high profile, contemporary topics, from folding, design and assembly through to dynamics and membrane transport.

Knowledge of the way in which proteins fold, assemble, self-polymerise, move and can be observed.

A) Protein Engineering: Protein stability; techniques used to study protein structure. Protein folding landscapes and pathways. Design of new proteins
B) Protein dynamics: methods used to study it, including NMR, hydrogen exchange/mass spectrometry and simulations. Role in protein function.
C) Membrane proteins/transporters and receptors, including methods to probe dynamics such as HDX-MS. Sym and Antiporters. ABC transporters. Ion channels.
D) Macromolecular machines and nanobiotechnology. How structural studies of macromolecular assemblies are leading to the development of nanodevices.

• Online discussion.
• Feedback on data handling problems.

Papers will additionally be recommended by individual lecturers.

Recommended Reading

1. Lesk, AM, Introduction to Protein Science Architecture, Function & Genomics (ISBN 987-0-19-954130), Oxford University Press, 2010, Recommended
2. Petsko, G & Ringe, D, Protein Structure and Function: Primers in Biology (ISBN 978-1-4051-1922-1), Wiley-Blackwell, 2003, Recommended
3. Whitford, D, Proteins: Structure and Function (ISBN: 0-471-49894-7), John Wiley & Sons Ltd, 2005, Recommended
4. Williamson, M, How Proteins Work (ISBN: 0815344465), Taylor & Francis 2011, Recommended

The year studying abroad is an integral part of the course and must be completed. Some costs, such as tuition fees, are substantially lower. Other costs can vary and are not included in the tuition fee. For example, living costs may be higher or lower than the UK, and there are travel-related costs to consider, such as paying for a passport, visa fees, health insurance, and (if needed) vaccinations.

All students should normally be able to complete their programme of study without incurring additional study costs over and above the tuition fee for that programme. Any unavoidable additional compulsory costs totalling more than 1% of the annual home undergraduate fee per annum, regardless of whether the programme in question is undergraduate or postgraduate taught, will be made clear to you at the point of application. Further information can be found in the University's (PDF document, 91KB).

Students participating in placements outside the UK may be able to apply for funding from the depending on eligibility. Priority will be given to students from low income households.